GHB chemistry...less risk.

The Society for the Preservation of Entheogenic Shamanism

in conjunction with:

Global Human Benefits


Butyrolactone half-life in humans approx 2 hours (1.5-2.5 hoursdepending on your metabolism)

2(3)-furanone di-hydro (2(3)FDH). It is a naturally occurring molecule that is ubiquitous in the body. It is particularly active within the central nervous system and is both a precursor to and a metabolite of gamma amino butyric acid (GABA). As with most neurochemicals, its precise action is unknown. However, it appears to block the action of dopamine (not the production) thus potentiating the effects of serotonin and GABA. It has a short half life (approximately 1.5 - 2.5 hours). After it is metabolized in the CNS, there is a relative surge of dopamine which accounts for the pleasant state of arousal that most users report. As with most other naturally occurring substances, it is metabolized to CO2 and water eliminating the toxicity inherent to other substances that are prescribed for these conditions. It is presently classified as a nutrient and is available in its present form without a prescription.

The legal status of GBL is being challanged. See the GHB Shaman (below) for more information on how you can help.

Read warning below for physical dependance information.

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The GHB Shaman: Global Human Benefits

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best when viewed on butyrolactone

WARNING: Do not use any substance if there is a history or the potential of mental or physical illness unless it has been shown to improve your condition or attitude. Do not use substances if you are on psychotropic pharmaceuticals or other types of drugs until you have researched possible interactions. GBL/GHB should not be mixed with alcohol, depressants, antihistamines, or any medication of this nature under any circumstances. Research interactions to anything you take with GBL/GHB carefully.

WARNING: Physical dependence is likely to develop in people previously dependant on opiods (possibly alcohol). When using to treat opiod withdrawals, use caution that the addiction is not transferred. Likewise, use caution when using opiods to assist with GBL/GHB withdrawals. DO NOT USE GBL/GHB TO TREAT CHRONIC MEDICAL DISORDERS. GBL/GHB withdrawals can be serious and intense.

PHYSICAL DEPENDANCE: Medical treatment should be sought immediately, and benzodiazepines should be prescribed by a physician for the withdrawals. Withdrawal symptoms: Intense anxiety, panic attacks, somatic waves, minor twitching, sleeplessness, depression, irritability, and opiod-like withdrawal symptoms. Withdrawal length depends on usage levels but generally: 2-12 weeks.


This page is not advocating the use of any particular substance. Chemical use should be an individual decision made after much research and thought. To deny people the ability to explore their religion and take their sacraments is horrible. For this reason, an honest source of information is required. There are many dangers in all things in life and this is not any different. This information is provided as a public service to educate. It is built on experience, research and submissions.