Lysergic Acid Amides

Wonderful Discovery; Plant Sources of LSA:

In 1959, the ethnobotanist Richard Schultes sent samples of a cultivated Mexican morning glory, Turbina corymbosa, to Albert Hoffman, the discoverer of LSD.  Schultes had seen it used by a Zapotec shaman.  In 1960, Hoffman analyzed the seeds and said they contained ergot-like alkaloids. This was hard for people to believe since previously such chemicals had only been found in the rye fungus Claviceps purpurea (ergot).  But Hoffman was right; the seeds contained d-lysergic acid amide.  This differs from LSD only in that it has a NH2 where LSD has a N(C2H5)2, but LSD is some 50 to 100 times as potent.  The morning glory Turbina corymbosa's seeds also have other psychoactive alkaloids in them: d-isolysergic acid amide, chanoclavine, elymoclavine, and lysergol.  

In 1960, Don Thomes MacDougall reported that seeds of another morning glory, Ipomoea violacea were used as sacraments by certain Zapotecs, sometimes with the Turbina corymbosa seeds and sometimes not.  This morning glory species is the one with familiar varieties in America: Heavenly Blue, Pearly Gates, Flying Saucers, Blue Star, Summer Skies and Wedding Bells. The Ipomoea violacea has the same psychoactive compounds in it except with ergometrine instead of lysergol.  Ergometrine has strong uterus-stimulating properties so it's a really bad idea for pregnant women to eat these seeds.  Also, these seeds are supposed to be bad for people with liver problems (e.g. jaundice, hepatitus).  These seeds are called badoh negro down in South America, since they are black, and some people think these were the mysterious tlitliltzin, which is the Nahuatl word for "black" with a reverential suffix.

Indications and Dosage

(LSA (ergine) is 1/10th as Potent as LSD-25 by weight):

Threshhold 0.2 mg
Common 0.5- 1.5 mg
Strong 1.5 - 4.0 mg
Heavy 4.0 mg
Do Not Dose More Than 4.0mg

Onset: 2 Hours or so to peak.
Duration : 10 - 14 hours
Normal After Effects : up to 24

1 MG (I. violacea) seed has about 0.01mg LSA.
1 HBWR seed has about 0.25mg LSA

WARNING: Has uterus-stimulating properties. DO NOT USE IF PREGNANT!

NOTE: Ergine: to get 1 good " Hit"* we need 100ug x 10 = 1mg ergine
(ergine is 1/10 potency of LSD). Thus we need 1.36 g of MG seeds (~100 seeds)
for one good hit, or 0.74 grams of HBWR seeds (~4 seeds).

*1960's LSD was on average 100ug per hit.

"I would agree, if you state that 200ug of LSD is the fully hallucinogenic dose, the 5 HBWR ingested was really close to 100-125ug.  I agree that each seed is equal to 25ug of LSD.

I would make the comparison between HBWR and Morning Glory, the same as I would ALD-52, and LSD-25.  The HBWR was much less somatically intoxicating and not speedy.

Based on this experience, I would project that 8 seeds would be a good trip, and 10-12 would be a "rock and roll trip"... and 14-16 would be "intense as hell," but possibility of alkaloid effects."

~~~~The Mystery Man 

MG: Morning Glory: Ipomoea violecea, nil, purpurpea etc.


HBWR: Hawaiian Baby Woodrose: Argyreia nervosa

Major Alkaloid Content in the Morning Glory seeds.

LAA% ; Total Alks. % by weight

Ololiuqui: 0.02; 0.04

Heavenly Blue: See Below*

Pearly Gates: 0.02; 0.03

Wedding Bells: 0.01; 0.03

Taken from : Isolation and Identification of Lysergic Acid Amide and Isolysergic Acid Amide as the Principal Ergoline Alkaloids in _Argyreia nervosa_, a tropical wood rose. Michael D. Miller (Bureau of Narcotics and Dangerous Drugs (cool how do I get his job?). Journal of the AOAC, vol 53(1):123-7, 1970.

*MG: Heavenly Blue (I. violacea) alkaloid percentages:

Picture of Ipomoea Violacea flower

d-Lysergic acid amide (ergine) = 0.035%
d-Isolysergic acid amide (isoergine) = 0.005%
Chanoclavine = 0.005%
Elymoclavine = 0.005%
Lysergol = ---%
* = 0.005%
Total alkaloids = 0.060%

*Ergometrine has uterus-stimulating properties. DO NOT USE IF PREGNANT!

ETHNOBOTANY; Evolution of Discipline,
edited by Shultes and von Reis...
from page 316, chapter written by Albert Hofmann:

NOTE: 1 (I. violacea) Seed has about 0.01mg LSA.

Seeds may lose potency with age and temperature of storage.

Note: the MG shell contains cyanogenic glycosides which can make you really sick if you eat enough (same kind of stuff in apple seeds) use an extraction process.

Major Alkaloid Content in the seeds of A. nervosa

Argyreia nervosa seeds

% of Total alkaloid; % dry seed weight

Ergine = 22.68% ; 0.136%
Isoergine = 31.36% ; 0.188%
Ergometrine* = 8.20% ; 0.049%
Lys. alpha-OH-ethylamide = 5.79% ; 0.035%
IsoLys. = 3.98 % ; 0.024%

*Ergometrine has uterus-stimulating properties. DO NOT USE IF PREGNANT!

Ergoline Alkaloidal Constituents of Hawaiian Baby Wood Rose, _Argyreia nervosa_ (Burm. f.) Bojer. Jew-Ming Chao and Ara H. Der Marderosian. Journal of Pharmaceutical Sciences 62(4):588-91. 1973.

NOTE: 1 HBWR seed has about 0.25mg LSA

HBWR: To dose, you don't have to remove all the shell, but just the dark-brown" stuff off loosely on the seed.  Then use the following method:  Grind the seeds up or crush really well.  Then soak the crushed/ground seeds in purified water for about 24 hours.  After the 24 hours, strain off the seed mass from the liquid using pantyhose, a sieve, cheesecloth, or if nothing else is available a coffee filter.  

Then to dose, drink the "tea" very slowly over a period of 20-40 minutes, and either drink a small glass of water, or a few large "gulps" after each sip of the "tea."  This process removes the "toxins" and reduces or negates the nausea sometimes associated with taking LSA containing seeds.

Note: the fuzzy "dark-brown" coating on the outside contains cyanogenic glycosides which can make you really sick if you eat enough (same kind of stuff in apple seeds).

NOTE:  You MUST use cold purified water for this process.  Tap water contains chemicals that break down the desired alkaloids.  Hot water also does this.

Seeds may lose potency with age and temperature of storage.


LSA:at the Lycaeum

LSD-25 Information

Mystery Man Tea

Mystery Man's LSA/LSD Trip Reports

How to get HBWR and/or MG Seeds


Back to Entheogens


     button5.gif (1949 bytes) Chesher Cat

The Mysterious Mind Behind The Madness


WARNING: Do not use any substance if there is a history or the potential of mental or physical illness unless it has been shown to improve your condition or attitude. Do not use substances if you are on psychotropic pharmaceuticals or other types of drugs until you have researched possible interactions.

WARNING: Ergometrine has uterus-stimulating properties. DO NOT USE IF PREGNANT!


This page is not advocating the use of any particular substance. Chemical use should be an individual decision made after much research and thought. To deny people the ability to explore their religion and take their sacraments is horrible. For this reason, an honest source of information is required. There are many dangers in all things in life and this is not any different. This information is provided as a public service to educate. It is built on experience, research and submissions.


updated 03-03-2000