Wonderous World of LSD

3-D LSD Molecule 2-D LSD Molecule

Lysergic Acid Diethylamide-25


Generic name for the hallucinogen lysergic acid diethylamide-25. Discovered by Dr. Albert Hofmann in 1938, LSD is one of the most potent mind-altering chemicals known. A white, odorless powder usually taken orally, its effects are highly variable and begin within one hour and generally last 8-12 hours, gradually tapering off. It has been used experimentally in the treatment of alcoholics and psychiatric patients. [Where it showed some success.] It significantly alters perception, mood, and psychological processes, and can impair motor coordination and skills. During the 1950s and early 1960s, LSD experimentation was legally conducted by psychiatrists and others in the health and mental health professions. Sometimes dramatic, unpleasant psychological reactions occur, including panic, great confusion, and anxiety. Strongly affected by SET and SETTING. Classification: hallucinogens. Slang names: acid, sugar. See also appendix B. (RIS 27:211-52 entries)

-- Research Issues 26, Guide to Drug Abuse Research Terminology, available from NIDA or the GPO, page 54.

Indications and Dosage:

Threshhold 20 ug
Common 50 - 150 ug
Strong 150 - 400 ug
Heavy 400 ug +
LD50 (Lethal Dose*) 14,000 ug +

Duration : 6 - 14 hours
Normal After Effects : up to 24 hours

* LD50 = dose which will kill 50% of the tested animals.

Psychedelics Encyclopedia (3rd Edition), p.70
Peter Stafford

"For those concerned about immediate medical hazards in ingesting LSD...Abram Hoffer has estimated, on the basis of animal studies, that the half-lethal human dose--meaning half would die--would be about 14,000 [ug]. But one person who took 40,000 ug survived. In the only case of death reportedly caused by overdose (Journal of the Kentucky Medical Association), the quantity of LSD in the blood indicated that 320,000 ug had been injected intravenously."

a) Analytical psychotherapy, to elicit release of repressed material and provide mental relaxation, particularly in anxiety states and obsessional neuroses. The initial dose is 25 ug. (1/4 of an ampoule or 1 tablet). This dose is increased at each treatment by 25 ug. until the optimum dose (usually between 50 and 200 ug.) is found. The individual treatments are best given at intervals of one week.

b) Experimental studies on the nature of psychoses: By taking Delysid himself, the psychiatrist is able to gain an insight in the world of ideas and sensations of mental patients. Delysid can also be used to induced model psychoses of short duration in normal subjects, this facilitating studies on the pathogenesis of mental disease.

In normal subjects, doses of 25 to 75 ug. are generally sufficient to produce a hallucinatory psychosis (on an average 1 ug./kg. body weight). In certain forms of psychosis and in chronic alcoholism, higher doses are necessary (2 to 4 ug./kg. body weight).

LSD TRIP REPORTS: Tales of The Mystery Man and The Grand Wazoo


Peripheral Actions

From: An Introduction to Pharmacology 3rd edition, JJ Lewis, 1964 (p 385)

These include an oxytocic action and constriction of the blood vessels of isolated vascular beds. In intact animals LSD causes a fall in blood pressure, but its adrenergic blocking potency is low.

LSD causes mydriasis in man and other species. It also causes hyperglycaemia and mydriasis, has a hyperthermic action and causes piloerection. These effects are sympathetic in nature and are abolished by ganglion blocking or adrenergic blocking agents. Parasympathetic effects include salivation, lachyrmation, vomiting, hypotension, and brachycardia. Low doses stimulate respiration but larger doses depress it.

(NB: mydriasis = pupillary dilation)

Hoffman thought the diethylamide version of the lysergic acid molecule might be a respiratory stimulant... (see Problem Child by Hoffman)

The "speedy" quality of unadulterated LSD is due to the pharmacological actions of LSD itself, and not necessarily due to decomposition or impurities. LSD typically causes early adrenergic effects such as sweating, nervousness, jaw grinding and insomnia which are easily confused with the side effects of amphetamine.

Most likely "good" acid is N-acetyl-LSD (ALD-52) [according to Psychedelic Encyclopedia it produces a smoother trip and is somewhat commonly found in analysis -- references to the latter were provided]. while "speedy" acid is LSD-25. You might want to inform her that those "speedy" effects are also commonly reported side effects of legal drugs which effect the 5-HT neurotransmitter system. And ditto on the potency issue -- you'd need mg quantities of strychnine to feel anything. And what you would feel (according to descriptions I've read) does not match descriptions of LSD "speed" effects. Most significantly because strychnine muscular effects tend to fade in & out, while LSD "speed" effects are typically reported as being consistent -- and there are other qualitative differences.



Zero physical addiction potential. Not something that makes you want to do it again immediately. Essentially zero psychological addiction potential.

Rarely people use it to escape in a negative way or as part of "polydrug abuse" behavior or pattern of behavior. Usually in this case other drugs are causing more harm, and the fundamental problem is a personal difficulty; the escapism/distraction is a symptom.


Pathological mental conditions may be intensified by Delysid. Particular caution is necessary in subjects with a suicidal tendency and in those cases where a psychotic development appears imminent. The psycho-affective lability and the tendency to commit impulsive acts may occasionally last for some days.



Several problems are associated with street drugs: their unknown purity and their unknown strength. Because of its extreme cheapness and potency, the purity of LSD in blotter form is not an issue: either it's lsd or untreated paper. The purity of powders, pills, and liquids cannot be assumed as safe. With regards to uncertain strength, the strength of hits these days is low, 100 micrograms or so. One should be careful and assume that the smallest square in a tiling of a sheet is a dose, even if a printed pattern covers several. An experienced person could judge the strength of a dose, and if it is assumed all doses on a sheet have been processed equivalently, those doses would be calibrated for others, much like anything else.

"There is a great deal of superstition regarding purification of psychedelics. Actually, any impurities which may be present as a result of synthetic procedures will almost certainly be without any effect on the trip. If there are 200 micrograms of LSD in a tablet, there could only be 200 mics of impurities present even if the LSD was originally only 50% pure (assuming nothing else has been added), and few compounds will produce a significant effect until a hundred to a thousand times this amount has been ingested. Even mescaline, which has a rather specific psychedelic effect, requires about a thousand times this amount."

Note that: 1) On a piece of paper, vs. a tablet, you can't even add significant amounts of adulterants. 2) Adulterants would cost, whereas blank paper will rip someone off just as well.

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